Metabolic Syndrome and the Risk for Chronic Kidney Disease among Nondiabetic Adults

doi:10.1681/ASN.2005010106


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Published ahead of print on May 18, 2005
Journal of the American Society of Nephrology
© 2005 American Society of Nephrology
doi: 10.1681/ASN.2005010106

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CLINICAL SCIENCE: Chronic Kidney Disease

Metabolic Syndrome and the Risk for Chronic Kidney Disease among Nondiabetic Adults

Manjula Kurella ¹, Joan C. Lo ², Glenn M. Chertow ³^*

*Nephrology

²
Endocrinology, Departments of Medicine; and Division of Research, Kaiser Permanente of Northern California, Oakland, California

³
*Nephrology; and Biostatistics and Epidemiology, University of California San Francisco, San Francisco

^* To whom correspondence should be addressed. E-mail: chertowg{at}medicine.ucsf.edu.

Abstract

The metabolic syndrome is a risk factor for the developmentof diabetes and cardiovascular disease; however, no prospectivestudies have examined the metabolic syndrome as a risk factorfor chronic kidney disease (CKD). A total of 10,096 nondiabeticparticipants who were in the Atherosclerosis Risk in Communitiesstudy and had normal baseline kidney function composed the studycohort. The metabolic syndrome was defined according to recentguidelines from the National Cholesterol Education Program.Incident CKD was defined as an estimated GFR (eGFR) <60 ml/minper 1.73 m² at study year 9 among those with an eGFR $≥$ 60 ml/minper 1.73 m² at baseline. After 9 yr of follow-up, 691 (7%) participantsdeveloped CKD. The multivariable adjusted odds ratio (OR) ofdeveloping CKD in participants with the metabolic syndrome was1.43 (95% confidence interval [CI], 1.18 to 1.73). Comparedwith participants with no traits of the metabolic syndrome,those with one, two, three, four, or five traits of the metabolicsyndrome had OR of CKD of 1.13 (95% CI, 0.89 to 1.45), 1.53(95% CI, 1.18 to 1.98), 1.75 (95% CI, 1.32 to 2.33), 1.84 (95%CI, 1.27 to 2.67), and 2.45 (95% CI, 1.32 to 4.54), respectively.After adjusting for the subsequent development of diabetes andhypertension during the 9 yr of follow-up, the OR of incidentCKD among participants with the metabolic syndrome was 1.24(95% CI, 1.01 to 1.51). The metabolic syndrome is independentlyassociated with an increased risk for incident CKD in nondiabeticadults.

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HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
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				T. A. Ikizler, P. Stenvinkel, and B. Lindholm Resolved: Being Fat Is Good for Dialysis Patients: The Godzilla Effect: Pro J. Am. Soc. Nephrol., June 1, 2008; 19(6): 1059 - 1064. [Abstract] [Full Text] [PDF]

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