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Published ahead of print on October 15, 2008
J Am Soc Nephrol 19: 2047-2051, 2008
© 2008 American Society of Nephrology
doi: 10.1681/ASN.2008060621
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Clinical Commentary

Hypertension-Associated Kidney Disease: Perhaps no More

Barry I. Freedman* and John R. Sedor{dagger}

* Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; and {dagger} Departments of Medicine and Physiology and Biophysics, Case Western Reserve University School of Medicine, and Kidney Disease Research Center, Rammelkamp Center for Research and Education, MetroHealth System Campus, Cleveland, Ohio

Correspondence: Dr. Barry I. Freedman, Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053. Phone: 336-716-6192; Fax: 336-716-4318; E-mail: bfreedma{at}wfubmc.edu

Despite common wisdom, the role of essential hypertension in the etiopathogenesis of ESRD has been controversial. Two recently published studies demonstrated a strong association of genetic variants in the gene that encodes the molecular motor protein nonmuscle myosin 2a (MYH9) with ESRD in African American patients without diabetes. These new data demonstrate that much of the excess risk of ESRD in African American individuals is attributable to an MYH9 risk haplotype and suggest that hypertension may cause progressive kidney disease only in genetically susceptible individuals or be the result of a primary renal disease.






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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673