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Presence of FoxP3⁺ Regulatory T Cells Predicts Outcome of Subclinical Rejection of Renal Allografts

Oriol Bestard^*, Josep M. Cruzado^*, Inés Rama^*, Joan Torras^*, Montse Gomà, Daniel Serón^*, Francesc Moreso^*, Salvador Gil-Vernet^* and Josep M. Grinyó^*

Departments of ^* Nephrology and Pathology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

Correspondence: Dr. Oriol Bestard, Nephrology Department, Hospital Universitari de Bellvitge, Barcelona, Spain. Phone: 0034932607614; Fax: 0034932607603; E-mail: 35830obm{at}comb.es

Received for publication November 7, 2007. Accepted for publication February 22, 2008.

Subclinical rejection (SCR) of renal allografts refers to histologic patterns of acute rejection despite stable renal function. The clinical approach to SCR is controversial; it would be helpful to identify biomarkers that could determine whether the identified cellular infiltrates were detrimental. For investigation of whether the presence of FoxP3⁺ regulatory T cells (Treg) could help determine the functional importance of tubulointerstitial infiltrates observed in 6-mo protocol biopsies, 37 cases of SCR were evaluated. The presence of FoxP3⁺ Treg discriminated harmless from injurious infiltrates, evidenced by independently predicting better graft function 2 and 3 yr after transplantation. Furthermore, the FoxP3⁺ Treg/CD3⁺ T cell ratio positively correlated with graft function at 2 yr after transplantation, suggesting that an increasing proportion of Treg within the global T cell infiltrate may facilitate renal engraftment; therefore, immunostaining for FoxP3⁺ Treg in patients with SCR on protocol biopsies may ultimately be useful to identify patients who may require alterations in their immunosuppressive regimens.

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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673