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Published ahead of print on June 13, 2007
J Am Soc Nephrol 18: 2032-2036, 2007
© 2007 American Society of Nephrology
doi: 10.1681/ASN.2006121328
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Pathophysiology of the Renal Biopsy

Nodular Glomerulosclerosis in the Nondiabetic Smoker

Samih H. Nasr and Vivette D. D'Agati

Department of Pathology, Columbia University, College of Physicians & Surgeons, New York, New York

Correspondence: Dr. Vivette D. D'Agati, Department of Pathology, Columbia University, College of Physicians & Surgeons, 630 West 168th Street, VC14-224, New York, NY 10032. Phone: 212-305-7460; Fax: 212-342-5380; E-mail: vdd1{at}columbia.edu

Emerging evidence supports that the entity known as idiopathic nodular glomerulosclerosis is not idiopathic. A strong causative association with longstanding cigarette smoking and hypertension has been identified. Morphologically, smoking-associated nodular glomerulosclerosis closely resembles diabetic nephropathy. The potential roles of advanced glycation end products, oxidative stress, angiogenesis, and hemodynamic perturbations are explored.




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S. R. Orth and S. I. Hallan
Smoking: A Risk Factor for Progression of Chronic Kidney Disease and for Cardiovascular Morbidity and Mortality in Renal Patients Absence of Evidence or Evidence of Absence?
Clin. J. Am. Soc. Nephrol., January 1, 2008; 3(1): 226 - 236.
[Abstract] [Full Text] [PDF]


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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673