2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) All Versions of this Article: ASN.2007040453v1 18/7/2014    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kopan, R. Articles by Surendran, K. Search for Related Content PubMed PubMed Citation Articles by Kopan, R. Articles by Surendran, K.

Molecular Insights into Segmentation along the Proximal–Distal Axis of the Nephron

Raphael Kopan^*, Hui-Teng Cheng^*, and Kameswaran Surendran^*

^* Departments of Molecular Biology and Pharmacology and Medicine, Washington University School of Medicine, St. Louis, Missouri; and Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan

Correspondence: Dr. Raphael Kopan, Department of Molecular Biology and Pharmacology and Department of Medicine at Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St. Louis, MO 63110. Phone: 314-747-5520; Fax: 314-362-7058; E-mail: kopan{at}wustl.edu

The structure of a mammalian kidney is parsed into large collections of polarized nephrons, and each segment is home to a diverse community of cells that specialize in renal endocrine and excretory functions. Early developmental lengthening and diversification of nephron segments along a proximal-–distal axis initiate all subsequent facets of tubular growth and function. Morphogenic cues and biochemical interactions that are critical to this process are starting to emerge. The underlying principles of regional cell signaling and transcriptional control organizing early segmentation are the subject of this review.

This article has been cited by other articles:

				S. S. El-Dahr, K. Aboudehen, and Z. Saifudeen Transcriptional control of terminal nephron differentiation Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1273 - F1278. [Abstract] [Full Text] [PDF]

				S. R. Singh and S. X. Hou Lessons Learned About Adult Kidney Stem Cells From the Malpighian Tubules of Drosophila J. Am. Soc. Nephrol., April 1, 2008; 19(4): 660 - 666. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673