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Glycemic Control and Critical Illness: Is the Kidney Involved?

Department of Medicine, University of California San Diego, San Diego, California

Correspondence: Dr. Ravindra L. Mehta, UCSD Medical Center 8342, 200 W. Arbor Drive, San Diego, CA 92103. Phone: 619-543-7310; Fax: 619-543-7420; E-mail: rmehta{at}ucsd.edu

The pathophysiology, consequences, and management of hyperglycemia during critical illness is an important clinical issue. Uncontrolled hyperglycemia in this setting is associated with a variety of adverse events, including mortality. The kidneys have a major role in glucose and insulin metabolism, and emerging evidence suggests that they both are actively involved in the development, maintenance, and resolution of hyperglycemia. The development of acute kidney injury is also a risk in this setting. This article discusses potential approaches for efficient and effective management of hyperglycemia.

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673