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Central Obesity, Incident Microalbuminuria, and Change in Creatinine Clearance in the Epidemiology of Diabetes Interventions and Complications Study

Ian H. de Boer^*,, Shalamar D. Sibley, Bryan Kestenbaum^*, Joshua N. Sampson, Bessie Young^||, Patricia A. Cleary^¶, Michael W. Steffes^**, Noel S. Weiss, John D. Brunzell for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group

Divisions of ^* Nephrology and Metabolism, Endocrinology, and Nutrition, Department of Biostatistics, ^|| Veterans’ Affairs Puget Sound Health Care System, Division of General Internal Medicine, and Department of Epidemiology, University of Washington, Seattle, Washington; Division of Diabetes/Endocrinology and ^** Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota; and ^¶ Biostatistics Center, George Washington University, Rockville, Maryland

Received for publication April 24, 2006. Accepted for publication October 4, 2006.

Weight gain and central obesity are associated with insulin resistance, hypertension, and dyslipidemia in type 1 diabetes. These metabolic abnormalities are risk factors for kidney disease in the general population, but data addressing the relationship of central obesity with kidney disease in type 1 diabetes are limited. Whether waist circumference is associated with incident microalbuminuria and change in creatinine clearance was examined among 1279 participants who had type 1 diabetes and were enrolled in the Epidemiology of Diabetes Interventions and Complications Study, the observational extension of the Diabetes Control and Complications Trial (DCCT). Ninety-three of 1105 participants with normal albumin excretion rate (AER) at DCCT closeout developed incident microalbuminuria over 5.8 yr of follow-up. The hazard ratio for incident microalbuminuria that was associated with each 10-cm greater waist circumference at DCCT closeout was 1.34 (95% confidence interval 1.07 to 1.68), after adjustment for DCCT closeout age, gender, duration of diabetes, treatment group, smoking status, glycosylated hemoglobin, and AER. This increased risk was modestly attenuated when additional adjustment was made for levels of BP and serum lipids. Creatinine clearance declined by an average of 0.34 ml/min per 1.73 m² each yr over 8 yr of follow-up. Greater rate of decline in creatinine clearance was associated with greater age, conventional insulin therapy during the DCCT, smoking, and greater glycosylated hemoglobin and AER at DCCT closeout but not with waist circumference. In conclusion, waist circumference predicts the subsequent development of microalbuminuria in type 1 diabetes. In contrast, no association of waist circumference with decline in creatinine clearance was observed.

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