2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) All Versions of this Article: ASN.2005091013v1 17/5/1253    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tipping, P. G. Articles by Holdsworth, S. R. Search for Related Content PubMed PubMed Citation Articles by Tipping, P. G. Articles by Holdsworth, S. R.

T Cells in Crescentic Glomerulonephritis

Centre for Inflammatory Diseases, Department of Medicine, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia

Address correspondence to: A/Prof. Peter G. Tipping, Monash University, Department of Medicine, Monash Medical Centre, 246 Clayton Rd, Clayton, Victoria, 3168 Australia. Phone: +61-39-594-5547; Fax: +61-39-594-6495; E-mail: peter.tipping{at}med.monash.edu.au

Crescent formation in glomerulonephritis (GN) is a manifestation of severe glomerular injury that usually results in a poor clinical outcome. In humans, crescentic GN is frequently associated with evidence of either systemic or organ-specific autoimmunity. T cells play a major role in initiation of adaptive immune responses that lead to crescentic injury. In experimental models of crescentic GN, Th1 predominant immune responses have been shown to promote crescent formation. Perturbation of regulatory T cell function may contribute to development of autoimmune crescentic GN. The presence of T cells and macrophages in crescentic glomeruli, frequently in the absence of humoral mediators of immunity, suggest a dominant effector role for T cells in crescentic GN. The association of cellular immune mediators with local fibrin deposition implicates cell-mediated "delayed-type hypersensitivity–like" mechanisms in crescent formation. Intrinsic renal cells also contribute to T cell–driven effector mechanisms in crescentic GN, via expression of MHC II and co-stimulatory molecules and by production of chemokines and cytokines that amplify leukocyte recruitment and injury.

This article has been cited by other articles:

				U. Panzer, G. Zahner, U. Wienberg, O. M. Steinmetz, A. Peters, J.-E. Turner, H.-J. Paust, G. Wolf, R. A. K. Stahl, and A. Schneider 15-Deoxy-{Delta}12,14-prostaglandin J2 inhibits INF-{gamma}-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells Nephrol. Dial. Transplant., July 2, 2008; (2008) gfn361v1. [Abstract] [Full Text] [PDF]

				C. Kurts Th17 cells: a third subset of CD4+ T effector cells involved in organ-specific autoimmunity Nephrol. Dial. Transplant., March 1, 2008; 23(3): 816 - 819. [Full Text] [PDF]

				J. Scholz, V. Lukacs-Kornek, D. R. Engel, S. Specht, E. Kiss, F. Eitner, J. Floege, H.-J. Groene, and C. Kurts Renal Dendritic Cells Stimulate IL-10 Production and Attenuate Nephrotoxic Nephritis J. Am. Soc. Nephrol., March 1, 2008; 19(3): 527 - 537. [Abstract] [Full Text] [PDF]

				T. Hidaka, Y. Suzuki, M. Yamashita, T. Shibata, Y. Tanaka, S. Horikoshi, and Y. Tomino Amelioration of Crescentic Glomerulonephritis by RhoA Kinase Inhibitor, Fasudil, through Podocyte Protection and Prevention of Leukocyte Migration Am. J. Pathol., March 1, 2008; 172(3): 603 - 614. [Abstract] [Full Text] [PDF]

				U. Panzer, O. M. Steinmetz, H.-J. Paust, C. Meyer-Schwesinger, A. Peters, J.-E. Turner, G. Zahner, F. Heymann, C. Kurts, H. Hopfer, et al. Chemokine Receptor CXCR3 Mediates T Cell Recruitment and Tissue Injury in Nephrotoxic Nephritis in Mice J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2071 - 2084. [Abstract] [Full Text] [PDF]

				M. Albaqumi, T. J. Soos, L. Barisoni, and P. J. Nelson Collapsing Glomerulopathy J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2854 - 2863. [Abstract] [Full Text] [PDF]

				P. G. Tipping Toll-Like Receptors: The Interface between Innate and Adaptive Immunity J. Am. Soc. Nephrol., July 1, 2006; 17(7): 1769 - 1771. [Full Text] [PDF]

				M. D. Morgan, L. Harper, J. Williams, and C. Savage Anti-Neutrophil Cytoplasm-Associated Glomerulonephritis J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1224 - 1234. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673