Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
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J Am Soc Nephrol 17: 291-295, 2006
© 2006 American Society of Nephrology
doi: 10.1681/ASN.2006080929

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Supplement Articles

New-Onset Diabetes after Kidney Transplantation: Risk Factors

Emilio Rodrigo, Gema Fernández-Fresnedo, Rosalía Valero, Juan Carlos Ruiz, Celestino Piñera, Rosa Palomar, Julio González-Cotorruelo, Carlos Gómez-Alamillo and Manuel Arias

Nephrology Service, University of Cantabria, Santander, Spain

Address correspondence to: Dr. Manuel Arias, Nephrology service, University of Cantabria, Avda. Valdecilla s/n 39008, Santander, Spain. Phone: +34942202738; Fax: +34942320415; E-mail: nefarm{at}humv.es

New-onset diabetes after transplantation (NODAT) contributes to the risk for cardiovascular disease and infection, reducing graft and patient survival. For improvement of the outcome of kidney transplant recipients, it is of great interest to know precisely the risk factors that contribute to NODAT development. Nonmodifiable risk factors for development of NODAT are age, race, genetic background, family history of diabetes, and previous glucose intolerance. Modifiable risk factors are obesity and overweight, hepatitis C virus and cytomegalovirus infections, and immunosuppressive drugs. Both steroids and calcineurin inhibitors influence the appearance of NODAT, whereas the role of sirolimus in glucose metabolism currently is controversial.




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