Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on March 30, 2005
J Am Soc Nephrol 16: 1413-1419, 2005
© 2005 American Society of Nephrology
doi: 10.1681/ASN.2004121100
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2004121100v1
16/5/1413    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jafar, T. H.
Right arrow Articles by Levey, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jafar, T. H.
Right arrow Articles by Levey, A. S.

Clinical Nephrology

Serum Creatinine as Marker of Kidney Function in South Asians: A Study of Reduced GFR in Adults in Pakistan

Tazeen H. Jafar*,{dagger},{ddagger}, Christopher H. Schmid§ and Andrew S. Levey{ddagger}

* Section of Nephrology, Department of Medicine, and {dagger} Clinical Epidemiology Unit, Department of Community Health Sciences, The Aga Khan University, Karachi, Pakistan; and {ddagger} Division of Nephrology, Department of Medicine, and § Division of Clinical Care Research, Department of Medicine, Tufts-New England Medical Center, Tufts University Medical School, Boston, Massachusetts

Address correspondence to: Dr. Tazeen H. Jafar, Section of Nephrology, Clinical Epidemiology Unit, Departments of Medicine & Community Health Sciences, Aga Khan University, P.O. Box 3500, Stadium Road, Karachi Sind 74800, Pakistan. Phone: 92-21-48594818; Fax: 92-21-4934294; E-mail: tazeen.jafar{at}aku.edu

Received for publication December 20, 2004. Accepted for publication February 18, 2005.

Migrant populations of South Asian origin have a higher risk for chronic kidney disease than the native whites. Several formulas have been developed to estimate kidney function from serum creatinine concentration. However, none of these has been validated in the South Asian population, which generally has different muscle mass composition than whites. A population-based cross-sectional study was performed on 262 individuals who were aged ≥40 yr in Karachi, Pakistan. Reduced GFR was defined as creatinine clearance (Ccr) measured in 24-h urine collection of <60 ml/min per 1.73 m2. Creatinine excretion was compared with age- and gender-matched white individuals by comparison of observed versus expected results on the basis of a formula using t test. The agreement among Cockcroft Gault (CG) Ccr and Modification of Diet in Renal Disease (MDRD) Study GFR equations was assessed by regression analyses, and the degree of accuracy of estimated versus measured GFR was determined. Mean (95% confidence interval) creatinine excretion was 1.7 (1.0 to 2.4) mg/kg per d lower than expected for age- and gender-matched white individuals (P < 0.001). The coefficient of determination for measured Ccr on the logarithmic scale was 66.7 and 55.6% for the CG and MDRD Study equations, respectively. The proportion of estimates within 20, 30, and 50% of measured Ccr values was 47.7 versus 32.8% (P < 0.001), 64.9 versus 49.6% (P < 0.001), and 79.4 versus 72.9 (P = 0.07) for CG versus MDRD Study equations, respectively. Lower mean creatinine excretion in these individuals may explain, in part, suboptimal agreement between estimated versus measured GFR. Inclusion of terms for ethnic and racial groups other than white and black might improve the performance of GFR estimating equations.




This article has been cited by other articles:


Home page
 CJASNHome page
R. Tagore, L. H. Ling, H. Yang, H.-Y. Daw, Y.-H. Chan, and S. K. Sethi
Natriuretic Peptides in Chronic Kidney Disease
Clin. J. Am. Soc. Nephrol., November 1, 2008; 3(6): 1644 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
S. W. Gao, D. K. Oliver, N. Das, F. P. Hurst, K. L. Lentine, L. Y. Agodoa, E. S. Sawyers, and K. C. Abbott
Assessment of Racial Disparities in Chronic Kidney Disease Stage 3 and 4 Care in the Department of Defense Health System
Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 442 - 449.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
T. H. Jafar, N. Chaturvedi, J. Hatcher, and A. S. Levey
Use of albumin creatinine ratio and urine albumin concentration as a screening test for albuminuria in an Indo-Asian population
Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2194 - 2200.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y.-C. Ma, L. Zuo, J.-H. Chen, Q. Luo, X.-Q. Yu, Y. Li, J.-S. Xu, S.-M. Huang, L.-N. Wang, W. Huang, et al.
Modified Glomerular Filtration Rate Estimating Equation for Chinese Patients with Chronic Kidney Disease
J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2937 - 2944.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. N. Hall, J. G. Sugihara, A. S. Go, and G. M. Chertow
Differential Mortality and Transplantation Rates among Asians and Pacific Islanders with ESRD
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3711 - 3720.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673