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Interactions between Angiotensin II and NF-B–Dependent Pathways in Modulating Macrophage Infiltration in Experimental Diabetic Nephropathy

Fiona T.H. Lee^*, Zemin Cao^*, David M. Long^*, Sianna Panagiotopoulos, George Jerums, Mark E. Cooper^* and Josephine M. Forbes^*

*Danielle Alberti Memorial Centre for Diabetes Complications, Vascular Division, Wynn Domain, Baker Medical Research Institute, Melbourne, Australia; and Department of Endocrinology, Austin Hospital, Heidelberg, Australia

Correspondence to Dr. Josephine M. Forbes, Division of Diabetic Complications, Baker Medical Research Institute, P.O. box 6492 St. Kilda Road Central, Melbourne 8008, Australia. Phone: 61–3–85321456; Fax: 61–3–85321288; E-mail: josephine.forbes{at}baker.edu.au

ABSTRACT. NF-B-dependent pathways play an important role in macrophage infiltration and kidney injury. NF-B is regulated by angiotensin II (AII). However, the role of this pathway in diabetic nephropathy has not been clearly delineated. First, the activation of NF-B, monocyte chemoattractant protein-1 (MCP-1), and macrophage infiltration in the diabetic kidney were explored, in a temporal manner. The active subunit of NF-B, p65, was elevated in the diabetic animals in association with increased MCP-1 gene expression and macrophage infiltration. Second, the effects of treatment for 4 wk with the AII type 1 receptor antagonist valsartan, the AII type 2 receptor antagonist PD123319, or pyrrolidine dithiocarbamate, an inhibitor of NF-B and on these parameters were assessed. These treatments were associated with a reduction in p65 activation, MCP-1 gene expression, and macrophage infiltration. These findings demonstrate a role for activation of NF-B, in particular the p65 subunit, in the pathogenesis of early renal macrophage infiltration in experimental diabetes. In the context of the known proinflammatory effects of AII, it is postulated that the renoprotection conferred by angiotensin II receptor antagonism is at least partly related to the inhibition of NF-B–dependent pathways.

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