2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Adamczak, M. Articles by Ritz, E. Search for Related Content PubMed PubMed Citation Articles by Adamczak, M. Articles by Ritz, E. Related Collections Related Article

Reversal of Glomerular Lesions Involves Coordinated Restructuring of Glomerular Microvasculature

Marcin Adamczak^*,, Marie-Luise Gross, Kerstin Amann and Eberhard Ritz^*

*Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany; Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland; Department of Pathology, University of Heidelberg, Heidelberg, Germany; and Department of Pathology, University of Erlangen-Nürnberg, Erlangen-Nürnberg, Germany

Correspondence to Dr. Marcin Adamczak, Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Francuska 20/24 Street 40-027 Katowice, Poland. Phone: +48-32-2552695; Fax: +48-32-2553726; E-mail:nefro{at}spskm.katowice.pl

There is increasing evidence from both human and experimental studies that at least partial reversal of glomerulosclerosis can be achieved by glomerular remodeling. This requires substantial changes in glomerular architecture, specifically of glomerular capillaries. It was the purpose of the present study to characterize the stereologic and topologic characteristics of glomerular capillaries when partial reversal of glomerular lesions is achieved by high-dose angiotensin-converting enzyme inhibitor treatment. Sham-operated male Sprague-Dawley rats were compared with subtotally nephrectomized (SNX) rats. The latter were kept untreated for 8 wk and subsequently randomly divided into one group that was continued without treatment and another group that was treated with enalapril (48 mg/kg body wt per d administered in the drinking fluid for 4 wk). Renal morphology was evaluated after 8 or 12 wk, respectively, by stereologic techniques after pressure-controlled perfusion fixation. In SNX rats at 8 and particularly at 12 wk, the glomerulosclerosis index was significantly higher than in sham-operated rats. At 12 wk, it was lower in rats that had been treated for 4 wk with enalapril compared with untreated SNX rats, suggesting partial reversal of glomerular lesions. This was associated with a decrease in mean glomerular volume and mean glomerular tuft volume, a reduced number of capillaries per glomerulus, and reduced total length of capillaries per glomerulus but without any significant change in the length of individual capillaries. The numerical capillary density (Euler number density) as an index of topologic complexity did not change. The total capillary surface area per glomerulus was strikingly increased after subtotal nephrectomy and partially reversed after enalapril. This was accounted for primarily by fewer capillaries without any change in diameter. In parallel, the number of endothelial cells per glomerulus was strikingly increased after subtotal nephrectomy and decreased with enalapril treatment, but endothelial cell volume remained elevated. The study shows harmonious coordinate remodeling of the entire glomerulus during regression of glomerular lesions after subtotal nephrectomy. Proportionate reduction of glomerular volume and capillary number without change of individual capillary length were found. The numerical capillary density of the tuft therefore remained unchanged.

Related Article

This Month’s Highlights
J. Am. Soc. Nephrol. 2004 15: 2955-2958. [Full Text] [PDF]

This article has been cited by other articles:

				G. Piecha, N. Koleganova, M.-L. Gross, A. Geldyyev, M. Adamczak, and E. Ritz Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination Am J Physiol Renal Physiol, July 1, 2008; 295(1): F137 - F144. [Abstract] [Full Text] [PDF]

				P. Ruggenenti, E. Perticucci, P. Cravedi, V. Gambara, M. Costantini, S. K. Sharma, A. Perna, and G. Remuzzi Role of Remission Clinics in the Longitudinal Treatment of CKD J. Am. Soc. Nephrol., June 1, 2008; 19(6): 1213 - 1224. [Full Text] [PDF]

				M. P. Cohen, G. T. Lautenslager, E. Hud, E. Shea, A. Wang, S. Chen, and C. W. Shearman Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency Am J Physiol Renal Physiol, February 1, 2007; 292(2): F789 - F795. [Abstract] [Full Text] [PDF]

				A. B. Fogo Progression versus regression of chronic kidney disease Nephrol. Dial. Transplant., February 1, 2006; 21(2): 281 - 284. [Full Text] [PDF]

				A. R. Chade, O. P. Mushin, X. Zhu, M. Rodriguez-Porcel, J. P. Grande, S. C. Textor, A. Lerman, and L. O. Lerman Pathways of Renal Fibrosis and Modulation of Matrix Turnover in Experimental Hypercholesterolemia Hypertension, October 1, 2005; 46(4): 772 - 779. [Abstract] [Full Text] [PDF]

				C. Chatziantoniou and J.-C. Dussaule Insights into the mechanisms of renal fibrosis: is it possible to achieve regression? Am J Physiol Renal Physiol, August 1, 2005; 289(2): F227 - F234. [Abstract] [Full Text] [PDF]

				G. Remuzzi and A. Remuzzi Is Regression of Chronic Nephropathies a Therapeutic Target? J. Am. Soc. Nephrol., April 1, 2005; 16(4): 840 - 842. [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673