2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Aben, J. A. Articles by de Heer, E. Search for Related Content PubMed PubMed Citation Articles by Aben, J. A. Articles by de Heer, E.

Genes Expressed by the Kidney, but Not by Bone Marrow-Derived Cells, Underlie the Genetic Predisposition to Progressive Glomerulosclerosis after Mesangial Injury

Joris A. Aben^*, Dennis A. Hoogervorst^*, Leendert C. Paul, Maria C. Borrias, Nancy A. Noble, Wayne A. Border, Jan A. Bruijn^* and Emile de Heer^*

Departments of *Pathology and Nephrology, Leiden University Medical Center, Leiden, The Netherlands; and Fibrosis Research Laboratory and Division of Nephrology, University of Utah, Salt Lake City, Utah.

Dr. Joris A. Aben, Department of Pathology, L1-Q Room P0-14, Leiden University Medical Center, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands. Phone: +31-71-526-6574; Fax: +31-71-524-8158;

ABSTRACT. Progressive renal failure is accompanied by uncontrolled accumulation of extracellular matrix in glomeruli and tubulointerstitium, eventually resulting in glomerulosclerosis. Although glomerulosclerosis occurs secondary to various renal diseases, the fact that not all patients develop progressive glomerulosclerosis suggests that genetic factors may underlie the tendency to progress, or not to progress. Identified were two Lewis rat substrains with small genetic differences but with considerable difference in resolution of glomerulonephritis after anti-Thy-1 administration. In the Lewis/Møllegard rat strain, anti-Thy-1 glomerulonephritis spontaneously resolves within 4 wk. In contrast, Lewis/Maastricht rats develop progressive glomerulosclerosis after induction of this disease. The involvement of bone marrow-derived cells and kidney cells in the development of glomerulosclerosis was determined. In the first study, exchange of bone marrow between these substrains did not affect the course of anti-Thy-1 nephritis. Lewis/Møllegard rats recovered rapidly, but Lewis/Maastricht rats showed progressive disease regardless of the genotype of the bone marrow they received. In the second study, kidneys were exchanged between the substrains. After transplantation, anti-Thy-1 nephritis was induced and glomerular damage assessed at day 21. Severe damage was observed in Lewis/Maastricht glomeruli independent of whether the kidney had been transplanted or not. Similarly, Lewis/Møllegard glomeruli, whether transplanted or not, revealed no residual histopathologic abnormalities. The inherited differences between the two substrains with regard to their insusceptibility to develop progressive glomerulosclerosis after mesangial injury are governed by genes expressed by the kidney, but not by bone marrow-derived cells. E-mail: J.A.Aben@lumc.nl

This article has been cited by other articles:

				D. H. T. IJpelaar, A. Schulz, J. Aben, A. van der Wal, J. A. Bruijn, R. Kreutz, and E. de Heer Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1 Physiol Genomics, October 8, 2008; 35(2): 173 - 181. [Abstract] [Full Text] [PDF]

				J. Smith, P.-C. Lai, J. Behmoaras, C. Roufosse, G. Bhangal, J. P McDaid, T. Aitman, F. W. Tam, C. D. Pusey, and H. T. Cook Genes Expressed by Both Mesangial Cells and Bone Marrow-Derived Cells Underlie Genetic Susceptibility to Crescentic Glomerulonephritis in the Rat J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1816 - 1823. [Abstract] [Full Text] [PDF]

				S.-M. Ka, A. Rifai, J.-H. Chen, C.-W. Cheng, H.-A. Shui, H.-S. Lee, Y.-F. Lin, L.-F. Hsu, and A. Chen Glomerular crescent-related biomarkers in a murine model of chronic graft versus host disease Nephrol. Dial. Transplant., February 1, 2006; 21(2): 288 - 298. [Abstract] [Full Text] [PDF]

				M. Eikmans, J. A. Aben, K. Koop, H. J. Baelde, E. de Heer, and J. A. Bruijn Genetic factors in progressive renal disease: the good ones, the bad ones and the ugly ducklings Nephrol. Dial. Transplant., February 1, 2006; 21(2): 257 - 260. [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673