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J Am Soc Nephrol 14:1901-1903, 2003
© 2003 American Society of Nephrology

TECHNICAL NOTE

Glomerular Structure in the Normal Human Kidney: Differences between Living and Cadaver Donors

M. Luiza Caramori, John M. Basgen and Michael Mauer

Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

Correspondence to Dr. Michael Mauer, 420 Delaware Street S.E., Mayo Mail Code 491, Minneapolis, MN 55455. Phone: 612-626-2922; Fax: 612-626-2791;

Abstract

ABSTRACT. Glomerular structure has been studied in tissues derived from normal living and cadaver kidney donors. Values obtained in such subjects were considered interchangeable and have been used to define the normal parameters when evaluating the effects of various renal diseases. The present study evaluated glomerular structure by light and electron microscopy in 83 living and 53 cadaver kidney donors. Glomerular basement membrane (GBM) width (356 ± 52 versus 329 ± 45 nm), glomerular volume (1.64 ± 0.47 versus 1.33 ± 0.39 x 106 µm3), and mesangial matrix volume per glomerulus (0.15 ± 0.05 versus 0.12 ± 0.04 x 106 µm3) were significantly greater in cadaver compared with living kidney donors, respectively. It is hypothesized that glomerular and extracellular matrix swelling is associated with the cadaver kidney preservation process. This study suggests that the normal values for glomerular structure should be derived only from living kidney donor tissues. E-mail: mauer002@tc.umn.edu






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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673