2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Erratum (v14,pA8) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vallon, V. Articles by Thomson, S. Search for Related Content PubMed PubMed Citation Articles by Vallon, V. Articles by Thomson, S.

Glomerular Hyperfiltration and the Salt Paradox in Early Type 1 Diabetes Mellitus: A Tubulo-Centric View

Volker Vallon^*, Roland C. Blantz and Scott Thomson

*Department of Pharmacology, University of Tübingen, Tübingen, Germany; Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego and San Diego Veterans Administration Medical Center, San Diego, California.

Correspondence to Dr. Volker Vallon, Department of Pharmacology, University of Tübingen, Wilhelmstr. 56, D-72074 Tübingen, Germany. Phone: 49-7071-297-2271; Fax: 49-7071-29-4942;

ABSTRACT. Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In major part, these outcomes derive from the high incidence of progressive kidney dysfunction in patients with diabetes making diabetic nephropathy a leading cause of end-stage renal disease. A better understanding of the early dysfunctions observed in the diabetic kidney may permit the development of new strategies to prevent diabetic nephropathy. This review proposes a "tubulo-centric" view of glomerular function in early type I diabetes mellitus. The following are particularly discussed (1) the primary role of an increase in reabsorption by the proximal tubule in early glomerular hyperfiltration, (2) the role of sodium-glucose cotransport and tubular growth under these conditions, and (3) the primary role of reabsorption by the proximal tubule for the paradoxical relationship between dietary salt and glomerular filtration rate. Finally, an outline is presented of potential therapeutic implications for the prevention of diabetic kidney disease. E-mail: volker.vallon@uni-tuebingen.de

This article has been cited by other articles:

				A. Chagnac, M. Herman, B. Zingerman, A. Erman, B. Rozen-Zvi, J. Hirsh, and U. Gafter Obesity-induced glomerular hyperfiltration: its involvement in the pathogenesis of tubular sodium reabsorption Nephrol. Dial. Transplant., July 12, 2008; (2008) gfn379v1. [Abstract] [Full Text] [PDF]

				S. P. Bagby Maternal Nutrition, Low Nephron Number, and Hypertension in Later Life: Pathways of Nutritional Programming J. Nutr., April 1, 2007; 137(4): 1066 - 1072. [Abstract] [Full Text] [PDF]

				G. Zerbini, R. Bonfanti, F. Meschi, E. Bognetti, P. L. Paesano, L. Gianolli, M. Querques, A. Maestroni, G. Calori, A. Del Maschio, et al. Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes Diabetes, September 1, 2006; 55(9): 2620 - 2625. [Abstract] [Full Text] [PDF]

				V. Vallon, B. Muhlbauer, and H. Osswald Adenosine and kidney function. Physiol Rev, July 1, 2006; 86(3): 901 - 940. [Abstract] [Full Text] [PDF]

				R. Loutzenhiser, K. Griffin, G. Williamson, and A. Bidani Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1153 - R1167. [Abstract] [Full Text] [PDF]

				M. W. Sanders, G. E. Fazzi, G. M.J. Janssen, C. E. Blanco, and J. G.R. De Mey High Sodium Intake Increases Blood Pressure and Alters Renal Function in Intrauterine Growth-Retarded Rats Hypertension, July 1, 2005; 46(1): 71 - 75. [Abstract] [Full Text] [PDF]

				V. Vallon, P. Wulff, D. Y. Huang, J. Loffing, H. Volkl, D. Kuhl, and F. Lang Role of Sgk1 in salt and potassium homeostasis Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R4 - R10. [Abstract] [Full Text] [PDF]

				S. C. Thomson, V. Vallon, and R. C. Blantz Kidney function in early diabetes: the tubular hypothesis of glomerular filtration Am J Physiol Renal Physiol, January 1, 2004; 286(1): F8 - F15. [Abstract] [Full Text] [PDF]

				D. R. Oldson, L. C. Moore, and H. E. Layton Effect of sustained flow perturbations on stability and compensation of tubuloglomerular feedback Am J Physiol Renal Physiol, November 1, 2003; 285(5): F972 - F989. [Abstract] [Full Text] [PDF]

				F. Locatelli, B. Canaud, K.-U. Eckardt, P. Stenvinkel, C. Wanner, and C. Zoccali The importance of diabetic nephropathy in current nephrological practice Nephrol. Dial. Transplant., September 1, 2003; 18(9): 1716 - 1725. [Abstract] [Full Text] [PDF]

				V. Vallon Tubuloglomerular Feedback and the Control of Glomerular Filtration Rate Physiology, August 1, 2003; 18(4): 169 - 174. [Abstract] [Full Text] [PDF]

				J. A. Miller, J. R. Curtis, and E. B. Sochett Relationship Between Diurnal Blood Pressure, Renal Hemodynamic Function, and the Renin-Angiotensin System in Type 1 Diabetes Diabetes, July 1, 2003; 52(7): 1806 - 1811. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673