Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by OJO, A. O.
Right arrow Articles by PORT, F. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by OJO, A. O.
Right arrow Articles by PORT, F. K.
J Am Soc Nephrol 12:589-597, 2001
© 2001 American Society of Nephrology

Survival in Recipients of Marginal Cadaveric Donor Kidneys Compared with Other Recipients and Wait-Listed Transplant Candidates

AKINLOLU O. OJO*, JULIE A. HANSON*, HERWIG-ULF MEIER-KRIESCHE*, CHIKE N. OKECHUKWU*, ROBERT A. WOLFE{dagger}, ALAN B. LEICHTMAN*, LAWRENCE Y. AGODOA§, BRUCE KAPLAN* and FRIEDRICH K. PORT*,{ddagger}

* Department of Medicine, University of Michigan, Ann Arbor, Michigan.
{dagger} Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.
{ddagger} Department of Epidemiology, University of Michigan, Ann Arbor, Michigan.
§ The United States Renal Data System, Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Correspondence to Dr. Akinlolu O. Ojo, Division of Nephrology, TC 3914, Box 0364, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, MI 48109-0364. Phone: 734-763-9041; Fax: 734-936-9621; E-mail: aojo{at}umich.edu

Abstract. An increasing number of cadaveric kidney transplants are now performed with organs from donors who would have been deemed unsuitable in earlier times. Although good allograft outcomes have been obtained with these marginal donor transplants, it is unclear whether recipients of marginal kidney transplants achieve a reduction in long-term mortality as do recipients of "ideal" kidneys. Patients with end-stage renal disease registered on the cadaveric renal transplant waiting list between January 1, 1992, and June 30, 1997, were studied for mortality risks according to three outcomes: wait-listed on dialysis treatment with no transplant (WLD); transplantation with marginal donor kidney (MDK); and "ideal" or optimal donor kidney transplantation (IDK). Thirty-four percent of wait-list registrants had received a cadaveric kidney transplant by June 30, 1998. Of these, 18% received a marginal kidney that had one or more of the following pretransplant factors: donor age >55 yr, non-heartbeating donor, cold ischemia time >36 h, and donor hypertension or diabetes mellitus of > 10 yr duration. Five-year graft and patient survival was 53% and 74% for MDK recipients compared with 67% (P < 0.001) and 80% (P < 0.001) for IDK recipients. Adjusted annual death rate and estimated remaining life time was 6.3%, 4.7%, and 3.3% and 15.3 yr, 20.4 yr, and 28.7 yr for WLD, MDK, and IDK groups, respectively. The average increase in life expectancy for MDK recipients compared with the WLD cohort was 5 yr, although this benefit varied from 3 to 10 yr depending on the recipient's characteristics. It is concluded that transplantation of a marginal kidney is associated with a significant survival benefit when compared with maintenance dialysis.




This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
W. Bentas, J. Jones, A. Karaoguz, U. Tilp, M. Probst, E. Scheuermann, I. A. Hauser, D. Jonas, and J. Gossmann
Renal transplantation in the elderly: surgical complications and outcome with special emphasis on the Eurotransplant Senior Programme
Nephrol. Dial. Transplant., June 1, 2008; 23(6): 2043 - 2051.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Delahousse, M. Chaignon, L. Mesnard, P. Boutouyrie, M. E. Safar, T. Lebret, M. Pastural-Thaunat, L. Tricot, A. Kolko-Labadens, A. Karras, et al.
Aortic Stiffness of Kidney Transplant Recipients Correlates with Donor Age
J. Am. Soc. Nephrol., April 1, 2008; 19(4): 798 - 805.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
W. Arns, F. Citterio, and J. M. Campistol
'Old-for-old'--new strategies for renal transplantation
Nephrol. Dial. Transplant., February 1, 2007; 22(2): 336 - 341.
[Full Text] [PDF]

Home page
 NEJMHome page
M. A. Josephson
Rabbit Antithymocyte Globulin or Basiliximab for Induction Therapy?
N. Engl. J. Med., November 9, 2006; 355(19): 2033 - 2035.
[Full Text] [PDF]

Home page
 CJASNHome page
A. J. Matas
Why We Should Develop a Regulated System of Kidney Sales: A Call for Action!
Clin. J. Am. Soc. Nephrol., November 1, 2006; 1(6): 1129 - 1132.
[Full Text] [PDF]

Home page
 CJASNHome page
P. P. Reese, A. L. Caplan, A. S. Kesselheim, and R. D. Bloom
Creating a Medical, Ethical, and Legal Framework for Complex Living Kidney Donors
Clin. J. Am. Soc. Nephrol., November 1, 2006; 1(6): 1148 - 1153.
[Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
D. J. Kutsogiannis, G. Pagliarello, C. Doig, H. Ross, and S. D. Shemie
Medical management to optimize donor organ potential: review of the literature: [Traitement medical pour optimaliser le potentiel de don d'organe : une revue documentaire].
Can J Anesth, August 1, 2006; 53(8): 820 - 830.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
A. I. Sanchez-Fructuoso, M. Marques, D. Prats, J. Conesa, N. Calvo, M. J. Perez-Contin, J. Blazquez, C. Fernandez, E. Corral, F. Del Rio, et al.
Victims of cardiac arrest occurring outside the hospital: a source of transplantable kidneys.
Ann Intern Med, August 1, 2006; 145(3): 157 - 164.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. S. Goldfarb-Rumyantzev, J. F. Hurdle, B. C. Baird, G. Stoddard, Z. Wang, J. D. Scandling, L. L. Barenbaum, and A. K. Cheung
The role of pre-emptive re-transplant in graft and recipient outcome
Nephrol. Dial. Transplant., May 1, 2006; 21(5): 1355 - 1364.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
A. S. Goldfarb-Rumyantzev, L. Smith, F. S. Shihab, B. C. Baird, A. N. Habib, S.-j. Lin, and L. L. Barenbaum
Role of Maintenance Immunosuppressive Regimen in Kidney Transplant Outcome
Clin. J. Am. Soc. Nephrol., May 1, 2006; 1(3): 563 - 574.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
A. S. Goldfarb-Rumyantzev, J. K. Koford, B. C. Baird, M. Chelamcharla, A. N. Habib, B.-J. Wang, S.-j. Lin, F. Shihab, and R. B. Isaacs
Role of Socioeconomic Status in Kidney Transplant Outcome
Clin. J. Am. Soc. Nephrol., March 1, 2006; 1(2): 313 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. Kandus, M. Arnol, and A. F. Bren
Renal transplantation in Slovenia after joining Eurotransplant
Nephrol. Dial. Transplant., January 1, 2006; 21(1): 36 - 39.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. M. Merion, V. B. Ashby, R. A. Wolfe, D. A. Distant, T. E. Hulbert-Shearon, R. A. Metzger, A. O. Ojo, and F. K. Port
Deceased-Donor Characteristics and the Survival Benefit of Kidney Transplantation
JAMA, December 7, 2005; 294(21): 2726 - 2733.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
G. Knoll, S. Cockfield, T. Blydt-Hansen, D. Baran, B. Kiberd, D. Landsberg, D. Rush, E. Cole, and for The Kidney Transplant Working Group of the Can
Canadian Society of Transplantation: consensus guidelines on eligibility for kidney transplantation
Can. Med. Assoc. J., November 8, 2005; 173(10): S1 - S25.
[Full Text] [PDF]

Home page
 Age AgeingHome page
F. Otero-Ravina, M. Rodriguez-Martinez, F. Gude, J. R. Gonzalez-Juanatey, F. Valdes, and D. Sanchez-Guisande
Renal transplantation in the elderly: does patient age determine the results?
Age Ageing, November 1, 2005; 34(6): 583 - 587.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
J. W. de Fijter and G. G. Persijn
Age, the riddle of renal transplantation
Nephrol. Dial. Transplant., November 1, 2005; 20(11): 2307 - 2310.
[Full Text] [PDF]

Home page
 JAMAHome page
A. J. Matas and D. E. R. Sutherland
The Importance of Innovative Efforts to Increase Organ Donation
JAMA, October 5, 2005; 294(13): 1691 - 1693.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. D. Schold, B. Kaplan, N. R. Chumbler, R. J. Howard, T. R. Srinivas, L. Ma, and H.-U. Meier-Kriesche
Access to Quality: Evaluation of the Allocation of Deceased Donor Kidneys for Transplantation
J. Am. Soc. Nephrol., October 1, 2005; 16(10): 3121 - 3127.
[Abstract] [Full Text] [PDF]

Home page
 BiostatisticsHome page
D. E. Schaubel and J. Cai
Analysis of clustered recurrent event data with application to hospitalization rates among renal failure patients
Biostat., July 1, 2005; 6(3): 404 - 419.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
C. C. Magee and M. Pascual
Update in Renal Transplantation
Arch Intern Med, July 12, 2004; 164(13): 1373 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
P. E. Morrissey, R. Gohh, A. Yango, A. Gautam, and A. P. Monaco
Renal Transplant Survival From Older Donors: A Single Center Experience
Arch Surg, April 1, 2004; 139(4): 384 - 389.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. S. Keith, A. Demattos, M. Golconda, J. Prather, and D. Norman
Effect of Donor Recipient Age Match on Survival after First Deceased Donor Renal Transplantation
J. Am. Soc. Nephrol., April 1, 2004; 15(4): 1086 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
K. C. Abbott, J. R. Bucci, C. S. Matsumoto, S. J. Swanson, L. Y.C. Agodoa, K. C. Holtzmuller, D. F. Cruess, and T. G. Peters
Hepatitis C and Renal Transplantation in the Era of Modern Immunosuppression
J. Am. Soc. Nephrol., November 1, 2003; 14(11): 2908 - 2918.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Bunnapradist, H. A. Gritsch, A. Peng, S. C. Jordan, and Y. W. Cho
Dual Kidneys from Marginal Adult Donors as a Source For Cadaveric Renal Transplantation in the United States
J. Am. Soc. Nephrol., April 1, 2003; 14(4): 1031 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Gourishankar, G. S. Jhangri, S. M. Cockfield, and P. F. Halloran
Donor Tissue Characteristics Influence Cadaver Kidney Transplant Function and Graft Survival but Not Rejection
J. Am. Soc. Nephrol., February 1, 2003; 14(2): 493 - 499.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. R. Bucci, C. S. Matsumoto, S. J. Swanson, L. Y. C. Agodoa, K. C. Holtzmuller, T. G. Peters, and K. C. Abbott
Donor Hepatitis C Seropositivity: Clinical Correlates and Effect on Early Graft and Patient Survival in Adult Cadaveric Kidney Transplantation
J. Am. Soc. Nephrol., December 1, 2002; 13(12): 2974 - 2982.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. M. Cecka
Donors without a Heartbeat
N. Engl. J. Med., July 25, 2002; 347(4): 281 - 283.
[Full Text] [PDF]

Home page
 NEJMHome page
S. D. Halpern, P. A. Ubel, and A. L. Caplan
Solid-Organ Transplantation in HIV-Infected Patients
N. Engl. J. Med., July 25, 2002; 347(4): 284 - 287.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. M. Danovitch, S. Hariharan, J. D. Pirsch, D. Rush, D. Roth, E. Ramos, R. C. Starling, C. Cangro, and M. R. Weir
Management of the Waiting List for Cadaveric Kidney Transplants: Report of a Survey and Recommendations by the Clinical Practice Guidelines Committee of the American Society of Transplantation
J. Am. Soc. Nephrol., February 1, 2002; 13(2): 528 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Research in NursingHome page
L. Piillips, S. J. Davies, and E. White
Health-related quality of life assessment in end-stage renal failure
Journal of Research in Nursing, May 1, 2001; 6(3): 658 - 670.
[Abstract] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673