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J Am Soc Nephrol 12:182-193, 2001
© 2001 American Society of Nephrology

REVIEW

Physiologic and Immunologic Hurdles to Xenotransplantation

BENJAMIN SAMSTEIN*,{dagger},{ddagger} and JEFFREY L. PLATT*

* Department of Surgery, Mayo Clinic, Rochester, Minnesota.
{dagger} Department of Immunology, Mayo Clinic, Rochester, Minnesota.
{ddagger} Department of Pediatrics, Mayo Clinic, Rochester, Minnesota.

Correspondence to Dr. Jeffrey L. Platt, Mayo Clinic, Medical Sciences Building, Room 2-66, Transplantation Biology, 200 1st Street S. W., Rochester, MN 55905. Phone: 507-538-0313; Fax: 507-284-4957; E-mail: platt.jeffrey{at}mayo.edu

Abstract. The major problem in the field of renal transplantation is currently the shortage of available kidneys. However, the use of animals as a source of kidneys, i.e., xenotransplantation, is increasingly being viewed as a potential solution to this problem. One preeminent hurdle to xenotransplantation is the immune response of the recipient against the graft; other hurdles include the physiologic limitations of the transplant, infection, and ethical considerations. This review summarizes what is currently known regarding the obstacles to xenotransplantation and some potential solutions to those problems.




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