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J Am Soc Nephrol 11:S95-S100, 2000
© 2000 American Society of Nephrology

Inducible Gene Expression and Gene Modification in Transgenic Mice

FRÉDÉRIC JAISSER

INSERM Unit 478, Medicine Faculty Xavier Bichat, Paris, France.

Correspondence to Dr. Frédéric Jaisser, INSERM Unit 478, Medicine Faculty Xavier Bichat, 16 rue Henri Huchard, 75018 Paris Cedex, France. Phone: 33-1-4485-6320; Fax: 33-1-4229-1644; E-mail: jaisser{at}bichat.inserm.fr

Abstract. Animal transgenesis has proven to be useful for physiologic as well as pathophysiologic studies. Animal models with conditional expression of a transgene of interest or with a conditional gene mutation can be generated. This permits spatial and temporal control of the expression of the transgene or of gene mutations previously introduced by gene targeting. These approaches allow the generation of models suitable for physiologic analysis or models mimicking disease states.




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