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J Am Soc Nephrol 11:S88-S94, 2000
© 2000 American Society of Nephrology

Transgenic Mice

An Irreplaceable Tool for the Study of Mammalian Development and Biology

CHARLES BABINET

Developmental Biology Unit, Pasteur Institute, URA CNRS 1960, Paris, France.

Correspondence to Dr. Charles Babinet, Institut Pasteur, Unité de Biologie du Développement, URA CNRS 1960, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: 33-1-4568-8559; Fax: 33-1-4568-8634; E-mail: chbabi{at}pasteur.fr

Abstract. Stable integration into the mouse genome of exogenous genetic information, i.e., the creation of transgenic mice, has become a privileged way of analyzing gene function in normal development and pathology. Both gene addition and gene replacement may be performed. This has allowed, in particular, the creation of mice in which precise mutations are introduced into a given gene. Furthermore, in recent years, strategies that induce the expression of a mutation in a given type of cell and/or at a given time in development have been developed. Thus, the transgenic methodology affords a unique and irreplaceable tool for the study of mammalian development and biology and for the creation of animal models for human genetic diseases.




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