 |
||||
| 2007 JASN IMPACT FACTOR 7.111 | HOME AUTHOR INFO EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP | |||
| CURRENT ISSUE | ARCHIVES | JASN Express | ONLINE SUBMISSION | |
|
||||
| 2007 JASN IMPACT FACTOR 7.111 | HOME AUTHOR INFO EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP | |||
| CURRENT ISSUE | ARCHIVES | JASN Express | ONLINE SUBMISSION | |
Department of Medicine, Division of Nephrology, Hennepin County Medical Center, Minneapolis, Minnesota.
Correspondence to Dr. Bertram L. Kasiske, Division of Nephrology, Department of Medicine, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415. Phone: 612-347-5871; Fax: 612-347-2003; E-mail: kasis001{at}tc.umn.edu
Abstract. Cigarette smoking increases the risk for cancer and cardiovascular disease in the general population, but the effects of smoking in renal transplant recipients are unknown. The effects of smoking were investigated among patients transplanted at Hennepin County Medical Center between 1963 and 1997. Information on smoking was available in 1334 patients. The 24.7% prevalence of smoking at the time of transplantation was similar to that in the general population. After adjusting for multiple predictors of graft failure, smoking more than 25 pack-years at transplantation (compared to smoking less than 25 pack-years or never having smoked) was associated with a 30% higher risk of graft failure (relative risk 1.30; 95% confidence interval [CI], 1.04 to 1.63; P = 0.021). Having quit smoking more than 5 yr before transplantation reduced the relative risk of graft failure by 34% (relative risk 0.66; 95% CI, 0.52 to 0.85; P < 0.001). The increase in graft failure was due to an increase in deaths (adjusted relative risk 1.42; 95% CI, 1.08 to 1.87; P = 0.012). The relative risk for major cardiovascular disease events with smoking 11 to 25 pack-years at transplant was 1.56 (95% CI, 1.06 to 2.31; P = 0.024), whereas that of smoking more than 25 pack-years was 2.14 (95% CI, 1.49 to 3.08; P < 0.001). The relative risk of invasive malignancies was 1.91 (95% CI, 1.05 to 3.48; P = 0.032). Smoking had no discernible effect on the rate of return to dialysis or on serum creatinine during the first year after transplantation. Thus, cigarette smoking is associated with an increased risk of death after renal transplantation. The effects of smoking appear to dissipate 5 yr after quitting. These results indirectly suggest that greater efforts to encourage patients to quit smoking before transplantation may decrease morbidity and mortality.
This article has been cited by other articles:
 |
|
 |
|
  A. C. Shirali and M. J. Bia Management of Cardiovascular Disease in Renal Transplant Recipients Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 491 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Gill Cardiovascular Disease in Transplant Recipients: Current and Future Treatment Strategies Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(Supplement_2): S29 - S37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Zitt, B. Kollerits, U. Neyer, W. Mark, D. Heininger, G. Mayer, F. Kronenberg, and K. Lhotta Cigarette smoking and chronic allograft nephropathy Nephrol. Dial. Transplant., October 1, 2007; 22(10): 3034 - 3039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. H. Nguyen, L. Galanti, Y. Pirson, and M. Jadoul Identification of current smokers among renal transplant recipients Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1974 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Marcen, J. M. Morales, M. Arias, G. Fernandez-Juarez, G. Fernandez-Fresnedo, A. Andres, E. Rodrigo, J. Pascual, B. Dominguez, and J. Ortuno Ischemic Heart Disease after Renal Transplantation in Patients on Cyclosporine in Spain J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S286 - S290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M.G.A. El-Ghar, M. Qureshi, A. Shoker, and K. Prasad Oxidative stress in renal transplant patients who develop cardiovascular disease. Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2006; 11(3): 203 - 210. [Abstract] [PDF]
|
|
|
|
|
|
B. Baggio, A. Budakovic, M. D. Vestra, A. Saller, M. Bruseghin, and P. Fioretto Effects of Cigarette Smoking on Glomerular Structure and Function in Type 2 Diabetic Patients J. Am. Soc. Nephrol., November 1, 2002; 13(11): 2730 - 2736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Briganti, R. Wolfe, G. R. Russ, J. M. Eris, R. G. Walker, and J. J. McNeil Graft loss following renal transplantation in Australia: is there a centre effect? Nephrol. Dial. Transplant., June 1, 2002; 17(6): 1099 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Briggs Causes of death after renal transplantation Nephrol. Dial. Transplant., August 1, 2001; 16(8): 1545 - 1549. [Full Text] [PDF]
|
|
|
|
|
|
S. R. Orth, H. Ogata, and E. Ritz Smoking and the kidney Nephrol. Dial. Transplant., October 1, 2000; 15(10): 1509 - 1511. [Full Text] [PDF]
|
|
|
|
|
|
B. L. KASISKE, M. A. VAZQUEZ, W. E. HARMON, R. S. BROWN, G. M. DANOVITCH, R. S. GASTON, D. ROTH, J. D. SCANDLING JR., and G. G. SINGER Recommendations for the Outpatient Surveillance of Renal Transplant Recipients J. Am. Soc. Nephrol., October 1, 2000; 11(2007): S1 - S86. [Abstract] [Full Text] [PDF]
|
|
|
HOME
CURRENT ISSUE
ARCHIVES
JASN Express
ONLINE SUBMISSION
AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP |
Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673
