2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by OHASHI, R. Articles by YAMANAKA, N. Search for Related Content PubMed PubMed Citation Articles by OHASHI, R. Articles by YAMANAKA, N.

Peritubular Capillary Injury during the Progression of Experimental Glomerulonephritis in Rats

Department of Pathology, Nippon Medical School, Tokyo, Japan.

Correspondence to Dr. Ryuji Ohashi, Department of Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyoku, Tokyo 113-8602, Japan. Phone: +81 3 3822 2131; Fax: +81 3 5685 3067; E-mail: r-ohashi{at}nms.ac.jp

Abstract. The functional and morphologic changes occurring in the peritubular capillaries (PTC) of the kidney during the progression of renal disease are not yet completely understood. In this study, the features of PTC disruption observed in a rat anti-glomerular basement membrane-induced glomerulonephritis (GN) model were characterized. Contributions to the progression of the disease made by other interstitial components, including ED-1-positive macrophages and CD3-positive T cells, were also investigated. Within 7 d of inducing GN, severe necrotizing glomerular injuries were observed. Thrombomodulin staining revealed that within 3 to 8 wk, there was a significant (P < 0.001) decline in the number of PTC, accompanied by a marked accumulation of macrophages, T cells, and fibrotic material. By the end of this period, most PTC were severely damaged or lost, and tubulointerstitial scarring was noted in the affected areas. Furthermore, PTC endothelial cell apoptosis occurred concomitantly, as shown by application of terminal deoxynucleotidyl transferasemediated dUTP-biotin nick end labeling methods and electron microscopy. It was presumed that the PTC injury was mediated possibly by the infiltrating macrophages and T cells, which, together with destruction of the PTC structure, correlated significantly with the impairment of renal function. These findings suggest that PTC disruption and the subsequent regression of the capillary network may contribute to the development of the tubulointerstitial injury largely responsible for the renal dysfunction in progressive GN.

This article has been cited by other articles:

				U. Sen, W. E. Rodriguez, N. Tyagi, M. Kumar, S. Kundu, and S. C. Tyagi Ciglitazone, a PPAR{gamma} agonist, ameliorates diabetic nephropathy in part through homocysteine clearance Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1205 - E1212. [Abstract] [Full Text] [PDF]

				A. Stoessel, A. Paliege, F. Theilig, F. Addabbo, B. Ratliff, J. Waschke, D. Patschan, M. S. Goligorsky, and S. Bachmann Indolent course of tubulointerstitial disease in a mouse model of subpressor, low-dose nitric oxide synthase inhibition Am J Physiol Renal Physiol, September 1, 2008; 295(3): F717 - F725. [Abstract] [Full Text] [PDF]

				Y. Iwazu, S. Muto, G. Fujisawa, E. Nakazawa, K. Okada, S. Ishibashi, and E. Kusano Spironolactone Suppresses Peritubular Capillary Loss and Prevents Deoxycorticosterone Acetate/Salt-Induced Tubulointerstitial Fibrosis Hypertension, March 1, 2008; 51(3): 749 - 754. [Abstract] [Full Text] [PDF]

				M. G. Wong, Y. Suzuki, C. Tanifuji, H. Akiba, K. Okumura, T. Sugaya, T. Yamamoto, S. Horikoshi, S. Y. Tan, C. Pollock, et al. Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis J. Am. Soc. Nephrol., February 1, 2008; 19(2): 290 - 297. [Full Text] [PDF]

				A. Sharabi, D. Luger, H. Ben-David, M. Dayan, H. Zinger, and E. Mozes The Role of Apoptosis in the Ameliorating Effects of a CDR1-Based Peptide on Lupus Manifestations in a Mouse Model J. Immunol., October 15, 2007; 179(8): 4979 - 4987. [Abstract] [Full Text] [PDF]

				D. Datta, O. Dormond, A. Basu, D. M. Briscoe, and S. Pal Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1222 - F1230. [Abstract] [Full Text] [PDF]

				W. M. Bernhardt, M. S. Wiesener, A. Weidemann, R. Schmitt, W. Weichert, P. Lechler, V. Campean, A. C. M. Ong, C. Willam, N. Gretz, et al. Involvement of Hypoxia-Inducible Transcription Factors in Polycystic Kidney Disease Am. J. Pathol., March 1, 2007; 170(3): 830 - 842. [Abstract] [Full Text] [PDF]

				C. Daniel, K. Amann, B. Hohenstein, P. Bornstein, and C. Hugo Thrombospondin 2 Functions as an Endogenous Regulator of Angiogenesis and Inflammation in Experimental Glomerulonephritis in Mice J. Am. Soc. Nephrol., March 1, 2007; 18(3): 788 - 798. [Abstract] [Full Text] [PDF]

				J. Li, J. A. Deane, N. V. Campanale, J. F. Bertram, and S. D. Ricardo The Contribution of Bone Marrow-Derived Cells to the Development of Renal Interstitial Fibrosis Stem Cells, March 1, 2007; 25(3): 697 - 706. [Abstract] [Full Text] [PDF]

				E. O'Riordan, N. Mendelev, S. Patschan, D. Patschan, J. Eskander, L. Cohen-Gould, P. Chander, and M. S. Goligorsky Chronic NOS inhibition actuates endothelial-mesenchymal transformation Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H285 - H294. [Abstract] [Full Text] [PDF]

				J. Li, J. A. Deane, N. V. Campanale, J. F. Bertram, and S. D. Ricardo Blockade of p38 Mitogen-Activated Protein Kinase and TGF-beta1/Smad Signaling Pathways Rescues Bone Marrow-Derived Peritubular Capillary Endothelial Cells in Adriamycin-Induced Nephrosis J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2799 - 2811. [Abstract] [Full Text] [PDF]

				W. Kim, S.-O. Moon, S. Y. Lee, K. Y. Jang, C.-H. Cho, G. Y. Koh, K.-S. Choi, K.-H. Yoon, M. J. Sung, D. H. Kim, et al. COMP-Angiopoietin-1 Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Model J. Am. Soc. Nephrol., September 1, 2006; 17(9): 2474 - 2483. [Abstract] [Full Text] [PDF]

				M. E.J. Reinders, T. J. Rabelink, and D. M. Briscoe Angiogenesis and Endothelial Cell Repair in Renal Disease and Allograft Rejection J. Am. Soc. Nephrol., April 1, 2006; 17(4): 932 - 942. [Abstract] [Full Text] [PDF]

				N. Kondo, H. Kiyomoto, T. Yamamoto, A. Miyatake, G.-P. Sun, M. Rahman, H. Hitomi, K. Moriwaki, T. Hara, S. Kimura, et al. Effects of Calcium Channel Blockade on Angiotensin II-Induced Peritubular Ischemia in Rats J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1047 - 1052. [Abstract] [Full Text] [PDF]

				M. Nangaku Chronic Hypoxia and Tubulointerstitial Injury: A Final Common Pathway to End-Stage Renal Failure J. Am. Soc. Nephrol., January 1, 2006; 17(1): 17 - 25. [Abstract] [Full Text] [PDF]

				L. K. Kairaitis, Y. Wang, M. Gassmann, Y.-C. Tay, and D. C. H. Harris HIF-1{alpha} expression follows microvascular loss in advanced murine adriamycin nephrosis Am J Physiol Renal Physiol, January 1, 2005; 288(1): F198 - F206. [Abstract] [Full Text] [PDF]

				M. Matsumoto, T. Tanaka, T. Yamamoto, E. Noiri, T. Miyata, R. Inagi, T. Fujita, and M. Nangaku Hypoperfusion of Peritubular Capillaries Induces Chronic Hypoxia before Progression of Tubulointerstitial Injury in a Progressive Model of Rat Glomerulonephritis J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1574 - 1581. [Abstract] [Full Text] [PDF]

				K. Manotham, T. Tanaka, M. Matsumoto, T. Ohse, T. Miyata, R. Inagi, K. Kurokawa, T. Fujita, and M. Nangaku Evidence of Tubular Hypoxia in the Early Phase in the Remnant Kidney Model J. Am. Soc. Nephrol., May 1, 2004; 15(5): 1277 - 1288. [Abstract] [Full Text] [PDF]

				D. P. Basile, K. Fredrich, D. Weihrauch, N. Hattan, and W. M. Chilian Angiostatin and matrix metalloprotease expression following ischemic acute renal failure Am J Physiol Renal Physiol, May 1, 2004; 286(5): F893 - F902. [Abstract] [Full Text] [PDF]

				K. Matsui, K. Nagy-Bojarsky, P. Laakkonen, S. Krieger, K. Mechtler, S. Uchida, S. Geleff, D.-H. Kang, R. J. Johnson, and D. Kerjaschki Lymphatic Microvessels in the Rat Remnant Kidney Model of Renal Fibrosis: Aminopeptidase P and Podoplanin Are Discriminatory Markers for Endothelial Cells of Blood and Lymphatic Vessels J. Am. Soc. Nephrol., August 1, 2003; 14(8): 1981 - 1989. [Abstract] [Full Text] [PDF]

				E. P. Bottinger and M. Bitzer TGF-{beta} Signaling in Renal Disease J. Am. Soc. Nephrol., October 1, 2002; 13(10): 2600 - 2610. [Abstract] [Full Text] [PDF]

				R. Ohashi, A. Shimizu, Y. Masuda, H. Kitamura, M. Ishizaki, Y. Sugisaki, and N. Yamanaka Peritubular Capillary Regression during the Progression of Experimental Obstructive Nephropathy J. Am. Soc. Nephrol., July 1, 2002; 13(7): 1795 - 1805. [Abstract] [Full Text] [PDF]

				D.-H. Kang, T. Nakagawa, L. Feng, and R. J. Johnson Nitric Oxide Modulates Vascular Disease in the Remnant Kidney Model Am. J. Pathol., July 1, 2002; 161(1): 239 - 248. [Abstract] [Full Text] [PDF]

				J. Rossert, W. M. McClellan, S. D. Roger, and D. L. Verbeelen Epoetin treatment: what are the arguments to expect a beneficial effect on renal disease progression? Nephrol. Dial. Transplant., March 1, 2002; 17(3): 359 - 362. [Full Text] [PDF]

				D.-H. Kang, J. Kanellis, C. Hugo, L. Truong, S. Anderson, D. Kerjaschki, G. F. Schreiner, and R. J. Johnson Role of the Microvascular Endothelium in Progressive Renal Disease J. Am. Soc. Nephrol., March 1, 2002; 13(3): 806 - 816. [Abstract] [Full Text] [PDF]

				J. P. Seery, V. Cattell, and F. M. Watt Cutting Edge: Amelioration of Kidney Disease in a Transgenic Mouse Model of Lupus Nephritis by Administration of the Caspase Inhibitor Carbobenzoxy-Valyl-Alanyl-Aspartyl-({beta}-o-methyl)-Fluoromethylketone J. Immunol., September 1, 2001; 167(5): 2452 - 2455. [Abstract] [Full Text] [PDF]

				E. Pillebout, M. Burtin, H. T. Yuan, P. Briand, A. S. Woolf, G. Friedlander, and F. Terzi Proliferation and Remodeling of the Peritubular Microcirculation after Nephron Reduction : Association with the Progression of Renal Lesions Am. J. Pathol., August 1, 2001; 159(2): 547 - 560. [Abstract] [Full Text]

				D.-H. KANG, A. H. JOLY, S.-W. OH, C. HUGO, D. KERJASCHKI, K. L. GORDON, M. MAZZALI, J. A. JEFFERSON, J. HUGHES, K. M. MADSEN, et al. Impaired Angiogenesis in the Remnant Kidney Model: I. Potential Role of Vascular Endothelial Growth Factor and Thrombospondin-1 J. Am. Soc. Nephrol., July 1, 2001; 12(7): 1434 - 1447. [Abstract] [Full Text] [PDF]

				D.-H. KANG, J. HUGHES, M. MAZZALI, G. F. SCHREINER, and R. J. JOHNSON Impaired Angiogenesis in the Remnant Kidney Model: II. Vascular Endothelial Growth Factor Administration Reduces Renal Fibrosis and Stabilizes Renal Function J. Am. Soc. Nephrol., July 1, 2001; 12(7): 1448 - 1457. [Abstract] [Full Text] [PDF]

				T. Suzuki, M. Kimura, M. Asano, Y. Fujigaki, and A. Hishida Role of Atrophic Tubules in Development of Interstitial Fibrosis in Microembolism-Induced Renal Failure in Rat Am. J. Pathol., January 1, 2001; 158(1): 75 - 85. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673