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J Am Soc Nephrol 11:1-8, 2000
© 2000 American Society of Nephrology

The Glomerular Slit Diaphragm Is a Modified Adherens Junction

JOCHEN REISER*, WILHELM KRIZ*, MATTHIAS KRETZLER{dagger} and PETER MUNDEL{ddagger}

* Department of Anatomy and Cell Biology, University of Heidelberg, Germany
{dagger} Department of Medicine, Ludwig-Maximilians-Universität, Munich, Germany
{ddagger} Departments of Medicine and Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York.

Correspondence to Dr. Peter Mundel, Division of Nephrology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: 718-430-3158; Fax: 718-430-8963; E-mail: mundel{at}aecom.yu.edu

Abstract. The glomerular slit diaphragm between podocyte foot processes shares typical morphologic features with an adherens junction. Differentiated cultured podocytes form cellular structures comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was coexpressed with P-cadherin as well as with {alpha}-, ß-, and {gamma}-catenin. In situ, P-cadherin was detected at the slit diaphragm in association with ZO-1 as shown by confocal microscopy and immunogold double labeling electron microscopy. P-cadherin expression in vivo and in vitro was confirmed by reverse transcription-PCR. These findings led to the concept that the slit diaphragm represents an adherens junction composed of P-cadherin, {alpha}-, ß-, and {gamma}-catenin, and ZO-1. In contrast to an adherens junction of a similar composition recently described in cultured fibroblasts, the slit diaphragm complex does not contain vinculin, which was found in nearby focal contacts. A P-cadherinbased adherens junction is well-suited to explain the zipper-like structure of the slit diaphragm. The present study should allow new avenues leading to the identification of additional slit diaphragm-associated proteins conferring specificity to this unique cell junction.




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