2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by VAN DEN HAM, E. C.H. Articles by VAN HOOFF, J. P. Search for Related Content PubMed PubMed Citation Articles by VAN DEN HAM, E. C.H. Articles by VAN HOOFF, J. P.

Body Composition in Renal Transplant Patients

Bioimpedance AnalysisCompared to Isotope Dilution, Dual Energy X-Ray Absorptiometry, andAnthropometry

EUGÉNIE C.H. VAN DEN HAM^*, JEROEN P. KOOMAN^*, MAARTEN H.L. CHRISTIAANS^*, FRED H.M. NIEMAN, BERNHARD K. VAN KREEL, GUIDO A.K. HEIDENDAL^§ and JOHANNES P. VAN HOOFF^*

^* Department of Internal Medicine, Division of Nephrology, University Hospital Maastricht, Maastricht, The Netherlands.
Methodology Section, University Hospital Maastricht, Maastricht, The Netherlands.
Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, The Netherlands.
^§ Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands.

Correspondence to Eugénie C.H. van den Ham, Department of Internal Medicine, Division Nephrology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands. Phone: 31 43 3875007; Fax: 31 43 3875006; E-mail: E.vandenham{at}intmed.unimaas.nl

Abstract. Whether multifrequency bioelectrical impedance analysis (MF-BIA), a relatively new method for measuring body composition, is also applicable for accurate body composition measurements in renal transplant (RTx) patients is not known. Therefore, the use of MF-BIA is validated in 77 RTx patients with a stable renal function at least 2 yr posttransplantation. MF-BIA is compared to isotope dilution techniques for measurement of body water compartments, and to dual energy x-ray absorptiometry (DEXA) and anthropometry for measurement of fat and fat free mass. Finally, DEXA and anthropometry are compared to each other. Method agreement is assessed by intraclass correlation coefficients (ICC) and plotted by Bland and Altman analysis. MF-BIA significantly underestimates total body water (TBW, 0.7 ± 2.1 L) and overestimates the extracellular water (ECW, 3.3 ± 1.8 L) compared to isotope dilution; the ICC between both techniques is 0.943 for TBW and 0.846 for ECW. The percentage body fat (BF) measured by MF-BIA is significantly higher than both BF measured by DEXA (3.4 ± 4.7%) or by anthropometry (5.5 ± 5.2%). The ICC between MF-BIA and DEXA is 0.887 and between MF-BIA and anthropometry 0.856. BF measured by DEXA is significantly higher than BF measured by anthropometry (2.1 ± 4.4%); their ICC is 0.913. In conclusion, MF-BIA seems to be suitable for measurement of TBW in RTx patients; however, method agreement between isotope dilution and MF-BIA for the measurement of ECW is not satisfactory. In the assessment of fat and fat free mass, the reliability of MF-BIA appears to be questionable. Method agreement between DEXA and anthropometry seems to be slightly better.

This article has been cited by other articles:

				G. Sun, C. R French, G. R Martin, B. Younghusband, R. C Green, Y.-g. Xie, M. Mathews, J. R Barron, D. G Fitzpatrick, W. Gulliver, et al. Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population Am. J. Clinical Nutrition, January 1, 2005; 81(1): 74 - 78. [Abstract] [Full Text] [PDF]

				C. M. Avesani, S. A. Draibe, M. A. Kamimura, M. Cendoroglo, A. Pedrosa, M. L. Castro, and L. Cuppari Assessment of body composition by dual energy X-ray absorptiometry, skinfold thickness and creatinine kinetics in chronic kidney disease patients Nephrol. Dial. Transplant., September 1, 2004; 19(9): 2289 - 2295. [Abstract] [Full Text] [PDF]

				C. Beerenhout, T. Dejagere, F. M. van der Sande, O. Bekers, K. M. Leunissen, and J. P. Kooman Haemodynamics and electrolyte balance: a comparison between on-line pre-dilution haemofiltration and haemodialysis Nephrol. Dial. Transplant., September 1, 2004; 19(9): 2354 - 2359. [Abstract] [Full Text] [PDF]

				J. Plum, G. Schoenicke, W. Kleophas, W. Kulas, F. Steffens, A. Azem, and B. Grabensee Comparison of body fluid distribution between chronic haemodialysis and peritoneal dialysis patients as assessed by biophysical and biochemical methods Nephrol. Dial. Transplant., December 1, 2001; 16(12): 2378 - 2385. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673