Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ORTH, S. R.
Right arrow Articles by RITZ, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ORTH, S. R.
Right arrow Articles by RITZ, E.
J Am Soc Nephrol 10:387-391, 1999
© 1999 American Society of Nephrology

BRIEF COMMUNICATIONS

The ETA Receptor Blocker LU 135252 Prevents Chronic Transplant Nephropathy in the "Fisher to Lewis" Model

STEPHAN R. ORTH*, GIULIO ODONI*, KERSTIN AMANN{dagger}, PIOTR STRZELCZYK*, MANFRED RASCHACK{ddagger} and EBERHARD RITZ*

* Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
{dagger} Department of Pathology, Ruperto Carola University, Heidelberg, Germany
{ddagger} Department of Knoll AG, Ludwigshafen/Rhein, Germany.

Correspondence to Dr. Stephan R. Orth, Medizinische Klinik, Bergheimer Strasse 56a, D-69115 Heidelberg, Germany. Phone: 49 6221 91120; Fax: 49 6221 162476.

Abstract

Abstract. The effect of the orally highly bioavailable and specific endothelin A (ETA) receptor antagonist LU 135252 was assessed in a model of chronic renal allograft nephropathy. Kidneys of Fisher rats were orthotopically grafted to Lewis rats. Fisher autografts and kidneys after uninephrectomy served as controls. All animals received low-dose cyclosporin A (CsA; 1.5 mg/kg body wt) for 10 d after surgery. Allotransplanted animals were then randomized to receive standard diet or a diet designed to deliver 30 mg of LU 135252/kg body wt per d for 35 wk. BP was monitored telemetrically. Treatment with LU 135252 did not affect systolic or diastolic pressure. Indices of glomerulosclerosis (GSI), and tubulointerstitial and vascular damage were measured. Chronic transplant nephropathy was almost completely prevented by LU 135252 compared with untreated allografts or kidneys of uninephrectomized controls, i.e., GSI 0.7 ± 0.12 versus 1.6 ± 0.25 (P < 0.001) versus 0.7 ± 0.06 (P < 0.001). Allograft weight and serum creatinine were significantly lower in treated versus untreated animals. The results are consistent with the notion that ETA receptor-mediated events play a role in the genesis of chronic transplant nephropathy.




This article has been cited by other articles:


Home page
 HypertensionHome page
Y. Wang, D. Babankova, J. Huang, G. M. Swain, and D. H. Wang
Deletion of Transient Receptor Potential Vanilloid Type 1 Receptors Exaggerates Renal Damage in Deoxycorticosterone Acetate-Salt Hypertension
Hypertension, August 1, 2008; 52(2): 264 - 270.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M.-Y. Chang, E. Parker, M. El Nahas, J. L. Haylor, and A. C.M. Ong
Endothelin B Receptor Blockade Accelerates Disease Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease
J. Am. Soc. Nephrol., February 1, 2007; 18(2): 560 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
K. Frank, M. Zeier, M.-L. Gross, R. Waldherr, E. Ritz, and K. Amann
Comprehensive immunohistological analysis of the endothelin system in human kidney grafts
Nephrol. Dial. Transplant., May 1, 2006; 21(5): 1365 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Guruli, B. R. Pflug, S. Pecher, V. Makarenkova, M. R. Shurin, and J. B. Nelson
Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops
Blood, October 1, 2004; 104(7): 2107 - 2115.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
B. Hocher, P. Kalk, T. Slowinski, M. Godes, A. Mach, S. Herzfeld, D. Wiesner, P. C. Arck, H.-H. Neumayer, and B. Nafz
ETA Receptor Blockade Induces Tubular Cell Proliferation and Cyst Growth in Rats with Polycystic Kidney Disease
J. Am. Soc. Nephrol., February 1, 2003; 14(2): 367 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
J. Adams, G. Odoni, H. Ogata, C. Viedt, K. Amann, E. Ritz, and S. R. Orth
Combination treatment with an ETA-receptor blocker and an ACE inhibitor is not superior to the respective monotherapies in attenuating chronic transplant nephropathy in a 'Fisher-to-Lewis' rat model
Nephrol. Dial. Transplant., May 1, 2002; 17(5): 780 - 787.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. F. Luscher and M. Barton
Endothelins and Endothelin Receptor Antagonists : Therapeutic Considerations for a Novel Class of Cardiovascular Drugs
Circulation, November 7, 2000; 102(19): 2434 - 2440.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Dhein, S. Hochreuther, C. a. d. Spring, K. Bollig, C. Hufnagel, and M. Raschack
Long-Term Effects of the EndothelinA Receptor Antagonist LU 135252 and the Angiotensin-Converting Enzyme Inhibitor Trandolapril on Diabetic Angiopathy and Nephropathy in a Chronic Type I Diabetes Mellitus Rat Model
J. Pharmacol. Exp. Ther., May 1, 2000; 293(2): 351 - 359.
[Abstract] [Full Text]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673