2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by MAMOUN, A.-H. Articles by BERGSTRÖM, J. Search for Related Content PubMed PubMed Citation Articles by MAMOUN, A.-H. Articles by BERGSTRÖM, J.

Evidence of Splanchnic-Brain Signaling in Inhibition of Ingestive Behavior by Middle Molecules

ABDEL-HAFIZ MAMOUN^*, PER SÖDERSTEN, BJÖRN ANDERSTAM^* and JONAS BERGSTRÖM^*

^* Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Department of Clinical Neuroscience, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.

Correspondence to Dr. Jonas Bergström, Divisions of Baxter Novum and Renal Medicine, Huddinge Sjukhus K56, S-141 86 Huddinge, Sweden. Phone: 46 8 585 83981; Fax: 46 8 7114742; E-mail: jonas.bergstrom{at}kfcmail.hs.sll.se

Abstract. Anorexia, nausea, and vomiting are common symptoms of uremic intoxication. Fractions in the middle molecule weight range, isolated from normal urine and uremic plasma ultrafiltrate, inhibit ingestive behavior in the rat. To investigate their site of action and specificity, male rats were injected intraperitoneally, intravenously, or intracerebroventricularly with concentrated fractions of uremic plasma ultrafiltrate or normal urine (molecular weight range: 1.0 to 5.0 kD) and tested for ingestive and sexual behavior. An intraperitoneal injection of 0.5 ml of urine fraction (10:1) or 2.0 ml of uremic plasma ultrafiltrate fraction (25:1) inhibited carbohydrate intake by 76.3 and 45.9%, respectively, but an intravenous injection had no effect. However, intravenous injection of higher doses inhibited carbohydrate ingestion. An intracerebroventricular injection of 5 or 10 µl of urine (20:1) middle molecule fraction inhibited carbohydrate intake by 13.4 and 41.6%, respectively. An injection of 5 or 10 µl of uremic plasma ultrafiltrate (125:1) middle molecule fraction inhibited carbohydrate intake by 22.6 and 49.5%, respectively. Injections of the corresponding fraction from normal plasma ultrafiltrate had no effect. Injection of urine or uremic plasma ultrafiltrate middle molecule fractions did not affect the display of sexual behavior. These results suggest that middle molecule fractions from uremic plasma ultrafiltrate or normal urine act in the splanchnic region and/or brain to inhibit food intake and that the effect is specific for ingestive behavior.

This article has been cited by other articles:

				C. W, Y. PX, L. BM, C. RD, M. DL, M. RH, I. H, O. MH, W. K, B.-J. K, et al. Anorexia and Cachexia in Renal Failure--Is Leptin the Culprit?: Role of Leptin and Melanocortin Signaling in Uremia-Associated Cachexia. J Clin Invest 115: 1659-1665, 2005 J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2245 - 2250. [Full Text] [PDF]

				M. Wright, G. Woodrow, S. O'Brien, E. Armstrong, N. King, L. Dye, J. Blundell, A. Brownjohn, and J. Turney Cholecystokinin and leptin: their influence upon the eating behaviour and nutrient intake of dialysis patients Nephrol. Dial. Transplant., January 1, 2004; 19(1): 133 - 140. [Abstract] [Full Text] [PDF]

				J. M. BARGMAN, K. E. THORPE, and D. N. CHURCHILL Relative Contribution of Residual Renal Function and Peritoneal Clearance to Adequacy of Dialysis: A Reanalysis of the CANUSA Study J. Am. Soc. Nephrol., October 1, 2001; 12(10): 2158 - 2162. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673