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Membranous Glomerulonephritis Induced in the Pig by Antibody to Angiotensin-Converting Enzyme

Considerations on Its Relevance to thePathogenesis of Human Idiopathic Membranous Glomerulonephritis

SHOICHI MARUYAMA^*, EDWARD CANTU, III, CESARE DEMARTINO^||, ADRIAN VLADUTIU^¶, PETER R. B. CALDWELL, CATHERINE Y. WANG, VIVETTE D'AGATI^§, GABRIEL GODMAN^§, DAVID M. STERN^*, and GIUSEPPE ANDRES^§

^* Department of Physiology, College of Physicians and Surgeons of Columbia University, New York, New York
Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York
^§ Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York
^|| Laboratorio Elettromicroscopia, Ospedale San Gallicano, Rome, Italy
^¶ Department of Pathology, State University of New York at Buffalo, Buffalo, New York.

Correspondence to Dr. Giuseppe Andres, Department of Physiology and Surgical Sciences, Room 17-401, Columbia Medical Center, 630 West 168th Street, New York, NY 10032. Phone: 212-305-1615, extension 0211; Fax: 212-305-5337.

Abstract. In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.

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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673