Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by FERVENZA, F. C.
Right arrow Articles by RABKIN, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FERVENZA, F. C.
Right arrow Articles by RABKIN, R.
J Am Soc Nephrol 10:43-50, 1999
© 1999 American Society of Nephrology

REGULAR ARTICLES

Intrarenal Insulin-Like Growth Factor-1 Axis after Unilateral Nephrectomy in Rat

FERNANDO C. FERVENZA, TANNY TSAO, FAY HSU and RALPH RABKIN

Research Service, Veterans Affairs Palo Alto Health Care System, and Department of Medicine, Stanford University School of Medicine, Stanford, California.

Correspondence to Dr. Ralph Rabkin, Veterans Affairs Palo Alto Health Care System (111R), 3801 Miranda Avenue, Palo Alto, Ca 94304. Phone: 650-858-3985; Fax: 650-849-0213; E-mail: Rabkin{at}Leland.Stanford.edu

Abstract. It has been suggested that insulin-like growth factor-1 (IGF-1) may play a role in early compensatory renal growth. Since IGF-1 action is influenced by IGF binding proteins (IGFBP), this study was conducted to characterize the changes in gene expression not only of IGF-1 and its receptor, but also of IGFBP in the hypertrophying kidney of adult and weanling rats 1 wk after removal of the other kidney. At this time, there were distinct age-dependent changes in the renal IGF-1 axis. In the mature kidney, IGF-1 mRNA levels fell without a change in kidney IGF-1 peptide content. Likewise, although IGFBP-2, -3, and -5 mRNA levels fell, membrane-associated IGFBP did not change. IGF-1 receptor mRNA levels and IGF-1 receptor number both fell. In the weanling kidneys, IGF-1 mRNA and peptide levels and IGF-1 receptor binding were unaltered. However, IGFBP-3, -4, and -5 mRNA levels were increased, as were plasma membrane-associated IGFBP. Although these changes in the intrarenal IGF-1 axis were distinct, it is difficult to conceive how in either the mature or immature rat they could contribute to the ongoing compensatory renal growth that occurs 1 wk after loss of kidney mass unless IGF-1 were acting in a synergistic manner with other growth promoters.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
S. D. Oldroyd, Y. Miyamoto, A. Moir, T. S. Johnson, A. M. El Nahas, and J. L. Haylor
An IGF-I antagonist does not inhibit renal fibrosis in the rat following subtotal nephrectomy
Am J Physiol Renal Physiol, March 1, 2006; 290(3): F695 - F702.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. HAYLOR, H. HICKLING, E. EL ETER, A. MOIR, S. OLDROYD, C. HARDISTY, and A. M. EL NAHAS
JB3, an IGF-I Receptor Antagonist, Inhibits Early Renal Growth in Diabetic and Uninephrectomized Rats
J. Am. Soc. Nephrol., November 1, 2000; 11(11): 2027 - 2035.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. Sheng, J. Li, K. A. McNulty, D. Avery, and T. R. Kleyman
Characterization of the Selectivity Filter of the Epithelial Sodium Channel
J. Biol. Chem., March 17, 2000; 275(12): 8572 - 8581.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673